Bioinformatics Analyst

Union:  Non-Union Number of Vacancies:  1 New or Replacement Position:  Replacement Site:  Princess Margaret Cancer Centre Department:  Research Reports to:  Senior Scientist Salary Range: $68,932 - $103,409 Per Year Hours:  37.5 Hours Per Week Shifts:  Day shifts Status:  Temporary Full-time

Closing Date:  June 12, 2026 Position Summary

We are seeking an enthusiastic and highly motivated full-time Bioinformatics Analyst to join our team, initially on a contract basis with the possibility of transition to a permanent position. Our lab focuses on understanding how the bone marrow microenvironment shapes hematopoiesis and leukemia, with a strong emphasis on single-cell and spatial approaches. The successful candidate will lead the computational analysis of single-cell RNA-seq, spatial transcriptomics, and T cell receptor (TCR) sequencing datasets, with a particular focus on integrating cellular states, clonal architecture, and spatial organization. This is a highly collaborative research environment with access to unique human datasets and ongoing projects in leukemia and bone marrow biology. The position offers the opportunity to work at the interface of computation and biology and to contribute to high-impact studies. Duties: Analyze and interpret single-cell RNA-seq, spatial transcriptomics, and TCR sequencing data Integrate multi-modal datasets, including scRNA-seq, spatial transcriptomics, TCR sequencing, and imaging data Perform cell-cell interaction, niche, and clonotype analyses Link T cell clonality with transcriptional states Collaborate closely with experimental team members to guide study design and data interpretation Contribute to manuscripts and collaborative research projects Master’s degree in computational biology, Bioinformatics, or a related field Experience with single-cell data analysis using Seurat, Scanpy, or similar tools Experience with TCR/BCR analysis is highly desirable Strong programming skills in R and/or Python Results-driven, with a strong sense of ownership and the ability to efficiently advance analyses and projects Ability to work independently as well as collaboratively within a multidisciplinary team Why join UHN? In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN. Competitive offer packages Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/ ) Close access to Transit and UHN shuttle service A flexible work environment Opportunities for development and promotions within a large organization Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.) Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration. All applications must be submitted before the posting close date. UHN uses email to communicate with selected candidates.  Please ensure you check your email regularly. Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application. UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known. We thank all applicants for their interest, however, only those selected for further consideration will be contacted.